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Biomicrofluidics / Volume 5 / Issue 1 / SPECIAL TOPIC: BIOLOGICAL MICROFLUIDICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (GUEST EDITOR: SUWAN JAYASINGHE)

Biomicrofluidics 5, 013406 (2011); http://dx.doi.org/10.1063/1.3553237 (14 pages)

Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

Ioannis K. Zervantonakis1, Chandrasekhar R. Kothapalli2, Seok Chung3, Ryo Sudo4, and Roger D. Kamm1,2

1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02319, USA
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
3School of Mechanical Engineering, Korea University, Seoul 136-713, South Korea
4Department of System Design Engineering, Keio University, Yokohama 223-8522, Japan

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(Received 17 September 2010; accepted 11 January 2011; published online 30 March 2011)

Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory.

© 2011 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. CONVENTIONAL AND MICROPATTERNING APPROACHES
  3. MICROFLUIDIC CELL CULTURE
    1. Microfluidic cell culture: Advantages and challenges
    2. Microfluidic studies of cell-cell interactions
      1. Mural-endothelial cell interactions
      2. Hepatocyte-endothelial cell interactions
      3. Tumor-endothelial cell interactions
      4. Other cell-cell interactions
    3. Tissue specimen culture in microfluidic devices
  4. CONCLUSIONS AND FUTURE OUTLOOK

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KEYWORDS and PACS

Keywords

biological tissues, bioMEMS, biomimetics, cellular biophysics, microfluidics, reviews, tissue engineering

PACS

  • 87.80.Ek

    Mechanical and micromechanical techniques

  • 85.85.+j

    Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

  • 87.85.Ox

    Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)

  • 07.10.Cm

    Micromechanical devices and systems

  • 47.85.Np

    Fluidics

  • 87.85.Lf

    Tissue engineering

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3553237

PUBLICATION DATA

ISSN

1932-1058 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

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