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Biomicrofluidics / Volume 4 / Issue 4 / SPECIAL TOPIC: OPTOFLUIDICS (GUEST EDITOR: AI QUN LIU)

Biomicrofluidics 4, 043001 (2010); http://dx.doi.org/10.1063/1.3511706 (23 pages)

Review Article: Recent advancements in optofluidic flow cytometer

Sung Hwan Cho1, Jessica M. Godin2, Chun-Hao Chen3, Wen Qiao2, Hosuk Lee2, and Yu-Hwa Lo1,2

1Materials Science and Engineering Program, University of California San Diego, La Jolla, California 92093-0418, USA
2Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, California 92093-0407, USA
3Department of Bioengineering, University of California San Diego, La Jolla, California 92093-0412, USA

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(Received 16 August 2010; accepted 14 October 2010; published online 30 December 2010)

There is an increasing need to develop optofluidic flow cytometers. Optofluidics, where optics and microfluidics work together to create novel functionalities on a small chip, holds great promise for lab-on-a-chip flow cytometry. The development of a low-cost, compact, handheld flow cytometer and microfluorescence-activated cell sorter system could have a significant impact on the field of point-of-care diagnostics, improving health care in, for example, underserved areas of Africa and Asia, that struggle with epidemics such as HIV/AIDS. In this paper, we review recent advancements in microfluidics, on-chip optics, novel detection architectures, and integrated sorting mechanisms.

© 2010 American Institute of Physics

Article Outline

  1. INTRODUCTION
    1. Flow cytometry—principles and applications in biomedical research
    2. Microfluidic flow cytometer, μFACS
  2. REVIEW ON RECENT ADVANCEMENT ON MICROFLUIDICS
    1. Hydrodynamic focusing
    2. Inertial effect (nonzero Re)
  3. MINIATURIZATION OF OPTICAL DETECTION SYSTEM
    1. Exclusion-based optical systems
    2. Multicolor detection employing COST coding technology
  4. MICROFLUIDIC FLUORESCENCE-ACTIVATED CELL SORTER (μFACS)
    1. Survey of μFACS
    2. Integrated μFACS using an on-chip piezoelectric actuator
  5. CONCLUSION

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KEYWORDS and PACS

Keywords

biological fluid dynamics, biomedical measurement, lab-on-a-chip, microfluidics

PACS

  • 87.85.gf

    Fluid mechanics and rheology

  • 87.80.Ek

    Mechanical and micromechanical techniques

  • 47.85.-g

    Applied fluid mechanics

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3511706

PUBLICATION DATA

ISSN

1932-1058 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    J. Knight, A. Vishwanath, J. Brody, and R. Austin, Phys. Rev. Lett. 80, 3863 (1998).

    C. Simonnet and A. Groisman, Appl. Phys. Lett. 87, 114104 (2005)APPLAB000087000011114104000001.

    J. Godin, V. Lien, and Y. Lo, Appl. Phys. Lett. 89, 061106 (2006)APPLAB000089000006061106000001.

    S. Cho, W. Qiao, F. Tsai, K. Yamashita, and Y. Lo, Appl. Phys. Lett. 97, 093704 (2010)APPLAB000097000009093704000001.


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