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Biomicrofluidics / Volume 2 / Issue 3 / REGULAR ARTICLES

Biomicrofluidics 2, 034105 (2008); http://dx.doi.org/10.1063/1.2973661 (11 pages)

Dielectrophoretic manipulation of particles in a modified microfluidic H filter with multi-insulating blocks

Nuttawut Lewpiriyawong, Chun Yang, and Yee Cheong Lam

School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore

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(Received 13 June 2008; accepted 22 July 2008; published online 11 August 2008)

The conventional microfluidic H filter is modified with multi-insulating blocks to achieve a flow-through manipulation and separation of microparticles. The device transports particles by exploiting electro-osmosis and electrophoresis, and manipulates particles by utilizing dielectrophoresis (DEP). Polydimethylsiloxane (PDMS) blocks fabricated in the main channel of the PDMS H filter induce a nonuniform electric field, which exerts a negative DEP force on the particles. The use of multi-insulating blocks not only enhances the DEP force generated, but it also increases the controllability of the motion of the particles, facilitating their manipulation and separation. Experiments were conducted to demonstrate the controlled flow direction of particles by adjusting the applied voltages and the separation of particles by size under two different input conditions, namely (i) a dc electric field mode and (ii) a combined ac and dc field mode. Numerical simulations elucidate the electrokinetic and hydrodynamic forces acting on a particle, with theoretically predicted particle trajectories in good agreement with those observed experimentally. In addition, the flow field was obtained experimentally with fluorescent tracer particles using the microparticle image velocimetry (μ-PIV) technique.

© 2008 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. MATERIALS AND METHODS
  3. MODELING OF PARTICLE’S MOTION
    1. Electrophoretic force
    2. Hydrodynamic and electro-osmotic force
    3. Dielectrophoretic force
  4. RESULTS AND DISCUSSION
    1. Effect of applied voltage
    2. Size-dependent separation of particles
    3. Reduction of the threshold voltage
    4. Further discussion
    5. Electro-osmotic flow field

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KEYWORDS and PACS

Keywords

bioMEMS, electrophoresis, flow control, flow separation, flow visualisation, microchannel flow, osmosis, polymers

PACS

  • 87.85.Ox

    Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)

  • 85.85.+j

    Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

  • 87.50.ch

    Electrophoresis/dielectrophoresis and other mechanical effects

  • 82.39.Wj

    Ion exchange, dialysis, osmosis, electro-osmosis, membrane processes

  • 47.85.Np

    Fluidics

  • 47.85.L-

    Flow control

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.2973661

PUBLICATION DATA

ISSN

1932-1058 (print)  
1932-1058 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    H. A. Pohl, J. Appl. Phys. 22, 869 (1951)JAPIAU000022000007000869000001.

    J. E. Gordon, Z. Gagnon, and H. -C. Chang, Biomicrofluidics 1, 044102 (2007)BIOMGB000001000004044102000001.

    I. F. Cheng, D. Hou, and H. -C. Chang, Biomicrofluidics 1, 021503 (2007)BIOMGB000001000002021503000001.

    G. O. F. Parikesit, A. P. Markesteijn, O. M. Piciu, A. Bossche, J. Westerweel, I. T. Young, and Y. Garini, Biomicrofluidics 2, 024103 (2008)BIOMGB000002000002024103000001.

    D. G. Yan, C. Yang, N. T. Nguyen, and X. Y. Huang, Phys. Fluids 19, 017114 (2007)PHFLE6000019000001017114000001.


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