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Biomicrofluidics / Volume 2 / Issue 3 / REGULAR ARTICLES

Biomicrofluidics 2, 034103 (2008); http://dx.doi.org/10.1063/1.2966453 (8 pages)

Design and integration of an all-in-one biomicrofluidic chip

Liyu Liu1, Wenbin Cao2, Jinbo Wu1, Weijia Wen1, Donald Choy Chang2, and Ping Sheng1

1Institute of Nano Science and Technology and Department of Physics, The Hong Kong University of Science and Technology Clear Water Bay, Kowloon, Hong Kong
2Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong

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(Received 5 May 2008; accepted 11 July 2008; published online 21 July 2008; corrected 14 December 2010)

We demonstrate a highly integrated microfluidic chip with the function of DNA amplification. The integrated chip combines giant electrorheological-fluid actuated micromixer and micropump with a microheater array, all formed using soft lithography. Internal functional components are based on polydimethylsiloxane (PDMS) and silver/carbon black-PDMS composites. The system has the advantages of small size with a high degree of integration, high polymerase chain reaction efficiency, digital control and simple fabrication at low cost. This integration approach shows promise for a broad range of applications in chemical synthesis and biological sensing/analysis, as different components can be combined to target desired functionalities, with flexible designs of different microchips easily realizable through soft lithography.

© 2008 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. EXPERIMENTS AND RESULTS

EDITORIALLY RELATED

  1. Publisher's Note: “Design and integration of an all-in-one biomicrofluidic chip” [Biomicrofluidics 2, 034103 (2008)]
    Liyu Liu et al.
    Biomicrofluidics 5, 019901 (2011)BIOMGB000005000001019901000001

RELATED DATABASES

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KEYWORDS and PACS

Keywords

bioMEMS, biosensors, carbon, lab-on-a-chip, lithography, microactuators, microfluidics, micropumps, organic compounds, silver

PACS

  • 87.85.Ox

    Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)

  • 85.85.+j

    Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

  • 85.40.Hp

    Lithography, masks and pattern transfer

  • 47.61.Fg

    Flows in micro-electromechanical systems (MEMS) and nano-electromechanical systems (NEMS)

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.2966453

PUBLICATION DATA

ISSN

1932-1058 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    X. Niu, M. Zhang, S. Peng, W. Wen, and P. Sheng, Biomicrofluidics 1, 044101 (2007)BIOMGB000001000004044101000001.

    L. Liu, S. Peng, W. Wen, and P. Sheng, Appl. Phys. Lett. 91, 093513 (2007)APPLAB000091000009093513000001.

    L. Liu, X. Chen, X. Niu, W. Wen, and P. Sheng, Appl. Phys. Lett. 89, 083505 (2006)APPLAB000089000008083505000001.

    X. Niu, L. Liu, W. Wen, and P. Sheng, Appl. Phys. Lett. 88, 153508 (2006)APPLAB000088000015153508000001.

    X. Niu, L. Liu, W. Wen, and P. Sheng, Phys. Rev. Lett. 97, 044501 (2006).

    L. Liu, S. Peng, X. Niu, and W. Wen, Appl. Phys. Lett. 89, 223521 (2006)APPLAB000089000022223521000001.


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