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Biomicrofluidics / Volume 1 / Issue 3 / REGULAR ARTICLES

Biomicrofluidics 1, 034103 (2007); http://dx.doi.org/10.1063/1.2766761 (10 pages)

Development of a direct three-dimensional biomicrofabrication concept based on electrospraying a custom made siloxane sol

Alice C. Sullivan1 and Suwan N. Jayasinghe2

1School of Biological & Chemical Sciences, Queen Mary, University of London, Walter Besant Building, Mile End Road, London E1 4NS, United Kingdom
2Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, United Kingdom

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(Received 22 May 2007; accepted 5 July 2007; published online 19 July 2007)

We demonstrate here the discovery of a unique and direct three-dimensional biomicrofabrication concept possessing the ability to revolutionize the jet-based fabrication arena. Previous work carried out on similar jet-based approaches have been successful in fabricating only vertical wall/pillar-structures by the controlled deposition of stacked droplets. However, these advanced jet-techniques have not been able to directly fabricate self-supporting arches/links (without molds or reaction methods) between adjacent structures (walls or pillars). Our work reported here gives birth to a unique type of jet determined by high intensity electric fields, which is derived from a specially formulated siloxane sol. The sol studied here has been chosen for its attractive properties (such as an excellent cross-linking nature as well as the ability to polymerize via polycondensation on deposition to its biocompatability), which promotes direct forming of biostructures with nanometer (<50 nm) sized droplets in three dimensions. We foresee that this direct three-dimensional biomicrofabrication jet technique coupled with a variety of formulated sols having focused and enhanced functionality will be explored throughout the physical and life sciences.

© 2007 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. MATERIALS AND METHODS
    1. Siloxane sol and electrospraying
    2. Generation of operational guides for each ground electrode configuration
  3. RESULTS AND DISCUSSION
  4. CONCLUSION

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KEYWORDS and PACS

Keywords

spray coating techniques, electric field effects, sols, nanobiotechnology, jets, dendritic structure, polymerisation, self-assembly

PACS

  • 81.16.Fg

    Supramolecular and biochemical assembly

  • 87.80.-y

    Biophysical techniques (research methods)

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.2766761

PUBLICATION DATA

ISSN

1932-1058 (print)  
1932-1058 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    D. Z. Wang, S. N. Jayasinghe, and M. J. Edirisinghe, Rev. Sci. Instrum. 76, 075105 (2005)RSINAK000076000007075105000001.


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