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Biomicrofluidics / Volume 1 / Issue 1 / REGULAR ARTICLES

Biomicrofluidics 1, 014103 (2007); http://dx.doi.org/10.1063/1.2409629 (13 pages)

Microfluidic blood plasma separation via bulk electrohydrodynamic flows

Dian R. Arifin, Leslie Y. Yeo, and James R. Friend

Micro/Nanophysics Research Laboratory, Department of Mechanical Engineering, Monash University, Clayton, VIC 3800, Australia

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(Received 9 October 2006; accepted 21 November 2006; published online 20 December 2006)

An effective mechanism for rapid and efficient microfluidic particle trapping and concentration is proposed without requiring any mechanically moving parts. When a voltage beyond the threshold atmospheric ionization value is applied on a sharp electrode tip mounted at an angle above a microfluidic liquid chamber, the bulk electrohydrodynamic air thrust that is generated results in interfacial shear and, hence, primary azimuthal liquid surface recirculation. This discharge driven vortex mechanism, in turn, causes a secondary bulk meridional liquid recirculation, which produces an inward radial force near the bottom of the chamber. Particles suspended in the liquid are then rapidly convected by the bulk recirculation toward the bottom, where the inward radial force causes them to spiral in a helical swirl-like fashion toward a stagnation point. In particular, we show that these flows, similar to Batchelor flows occurring in a cylindrical liquid column between a stationary and rotating disk, can be used for the separation of red blood cells from blood plasma in a miniaturized device.

© 2006 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. EXPERIMENTAL METHOD
  3. RESULTS AND DISCUSSION
    1. Physical mechanism
    2. Experimental observations
  4. CONCLUSION

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KEYWORDS and PACS

Keywords

blood, cellular biophysics, separation, microfluidics, electrohydrodynamics, vortices, patient diagnosis

PACS

  • 87.80.-y

    Biophysical techniques (research methods)

  • 87.17.-d

    Cell processes

  • 47.85.Np

    Fluidics

  • 85.85.+j

    Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

  • 47.65.-d

    Magnetohydrodynamics and electrohydrodynamics

  • 47.32.-y

    Vortex dynamics; rotating fluids

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.2409629

PUBLICATION DATA

ISSN

1932-1058 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    M. Toner and D. Irimia, Annu. Rev. Biomed. Eng. 7, 77 (2005)PFLDAS000015000001000004000001.

    L. Y. Yeo, D. Hou, S. Maheshswari, and H.-C. Chang, Appl. Phys. Lett. 88, 233512 (2006)APPLAB000088000023233512000001.

    L. Y. Yeo, J. R. Friend, and D. R. Arifin, Appl. Phys. Lett. 89, 103516 (2006)APPLAB000089000010103516000001.


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